Intelligent Signal Systems Laboratory at the University of Dayton is a world class research laboratory in image processing and computer vision. Our research focuses on three areas: physical and statistical modeling of image sensors, algorithmic development for exploitation of image data, and making meaningful inferences on the observed scene. The principal investigator is Keigo Hirakawa, an assistant professor at the University of Dayton. Research at ISSL is aimed at understanding the increasingly large role that signal systems play in the real-world. We connect the applied design efforts with the first principle ideas of mathematics and statistics to enable new capabilities in image processing and computer vision.